|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
We speculated that SH3PXD2A may take part in the pathogenesis of PE through its role in the regulation of trophoblast cell invasion in the period of placenta formation.
|
23544093 |
2013 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We investigated the prognostic significance of Tks5 and cortactin expression in 57 patients with various grades of glioma.
|
22249020 |
2012 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
They included secreted factors (CSF2, SDF-1), proteolytic enzymes (MMP9, CST7), cytoskeleton modulators (SDC2, Twinfilin, SH3PXD2A), intracellular signaling molecules (DUSP1, SPHK1, RASD1) and transcription factors (Sox9, SNAI2, SMAD3) functioning in epithelium to mesenchyme transition (EMT), tissue invasion, as well as homing and attachment to bone.
|
20863401 |
2010 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest a prognostic relevance for the Tks5 invadopodial protein in glial-derived brain tumours.
|
22249020 |
2012 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that tipping the Tks5 isoform balance to a high Tks5long to Tks5short ratio promotes invadopodia-mediated invasion and metastasis.
|
23873940 |
2013 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that tipping the Tks5 isoform balance to a high Tks5long to Tks5short ratio promotes invadopodia-mediated invasion and metastasis.
|
23873940 |
2013 |
|
Neurofibrosarcoma
|
0.300 |
FusionGene
|
disease |
ORPHANET |
The genomic landscape of schwannoma.
|
27723760 |
2016 |
|
Malignant Peripheral Nerve Sheath Tumor
|
0.300 |
FusionGene
|
disease |
ORPHANET |
The genomic landscape of schwannoma.
|
27723760 |
2016 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Rescue experiments suggested that SH3PXD2A-ASl-mediated oncogenesis was impaired by overexpression of P57 or KLF2.
|
29734178 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rescue assays were used to determine whether P57 and Kruppel-like factor 2 (KLF2) were involved in SH3PXD2A-ASl-dependent CRC proliferation.
|
29734178 |
2018 |
|
Electrocardiogram: P-R interval
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
|
30046033 |
2018 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Our research has identified several examples in which reduced VEGF-A binding to deficient vascular extracellular matrix leads to deficits in tumor vascularization and tumor growth: (1) germline ablation of collagen VI in the stroma of intracranial B16F10 melanomas; (2) knockdown of the Tks5 scaffolding protein in MDA-MB-231 mammary tumor cells; (3) germline ablation of NG2 proteoglycan in the stroma of MMTV-PyMT mammary tumors; and (4) myeloid-specific ablation of NG2 in the stroma of intracranial B16F10 melanomas.
|
28788063 |
2017 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
CTD_human |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Acute Cerebrovascular Accidents
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, metastatic melanoma cases showed higher expression of Tks5 than primary melanoma cases.
|
27802184 |
2016 |
|
Gestational Diabetes
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Methylation in six out of nine (67%) gestational diabetes-associated genes was validated and we also showed that methylation of SH3PXD2A was significantly (P<0.05) associated with multiple adiposity-related outcomes.
|
29461653 |
2018 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
28416818 |
2017 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.
|
17440933 |
2007 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
|
Paroxysmal atrial fibrillation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |